Polygenic prediction of body mass index and obesity through the life course and across ancestries

634

Smit, Roelof A J; Wade, Kaitlin H; Hui, Qin; Arias, Joshua D; Yin, Xianyong; Christiansen, Malene R; Yengo, Loic; Preuss, Michael H; Nakabuye, Mariam; Rocheleau, Ghislain; Graham, Sarah E; Buchanan, Victoria L; Chittoor, Geetha; Graff, Marielisa; Guindo-Martínez, Marta; Lu, Yingchang; Marouli, Eirini; Sakaue, Saori; Spracklen, Cassandra N; Vedantam, Sailaja; Wilson, Emma P; Chen, Shyh-Huei; Ferreira, Teresa; Ji, Yingjie; Karaderi, Tugce; Lüll, Kreete; Machado, Moara; Malden, Deborah E; Medina-Gomez, Carolina; Moore, Amy; Rüeger, Sina; Akiyama, Masato; Allison, Matthew A; Alvarez, Marcus; Andersen, Mette K; Appadurai, Vivek; Arbeeva, Liubov; Bartell, Eric; Bhaskar, Seema; Bielak, Lawrence F; Bis, Joshua C; Bollepalli, Sailalitha; Bork-Jensen, Jette; Bradfield, Jonathan P; Bradford, Yuki; Brandl, Caroline; Braund, Peter S; Brody, Jennifer A; Broeckel, Ulrich; Burgdorf, Kristoffer S; Cade, Brian E; Cai, Qiuyin; Camarda, Silvia; Campbell, Archie; Cañadas-Garre, Marisa; Chai, Jin-Fang; Chesi, Alessandra; Choi, Seung Hoan; Christofidou, Paraskevi; Couture, Christian; Cuellar-Partida, Gabriel; Danning, Rebecca; Degenhardt, Frauke; Delgado, Graciela E; Delitala, Alessandro; Demirkan, Ayşe; Deng, Xuan; Dietl, Alexander; Dimitriou, Maria; Dimitrov, Latchezar; Dorajoo, Rajkumar; Eichelmann, Fabian; Eliasen, Anders U; Engmann, Jorgen E; Erdos, Michael R; Fairhurst-Hunter, Zammy; Farmaki, Aliki-Eleni; Faul, Jessica D; Fernandez-Lopez, Juan-Carlos; Forer, Lukas; Frank, Mirjam; Freitag-Wolf, Sandra; Fritsche, Lars G; Fuchsberger, Christian; Galesloot, Tessel E; Gao, Yan; Geller, Frank; Giannakopoulou, Olga; Giulianini, Franco; Gjesing, Anette P; Goel, Anuj; Gordon, Scott D; Gorski, Mathias; Grove, Jakob; Guo, Xiuqing; Gustafsson, Stefan; Haessler, Jeffrey; Hansen, Thomas F; Havulinna, Aki S; Haworth, Simon J; Heard-Costa, Nancy; Hemerich, Daiane; Highland, Heather M; Hindy, George; Ho, Yuk-Lam; Hofer, Edith; Holliday, Elizabeth; Horn, Katrin; Hornsby, Whitney E; Hottenga, Jouke-Jan; Huang, Hongyan; Huang, Jie; Huerta-Chagoya, Alicia; Huo, Shaofeng; Hwang, Mi Yeong; Hwu, Chii-Min; Iha, Hiroyuki; Ikeda, Daisuke D; Isono, Masato; Jackson, Anne U; Jansen, Iris E; Jiang, Yunxuan; Johansson, Ingegerd; Jonsson, Anna; Jørgensen, Torben; Kalafati, Ioanna P; Kanai, Masahiro; Kanoni, Stavroula; Kårhus, Line L; Kasturiratne, Anuradhani; Katsuya, Tomohiro; Kawaguchi, Takahisa; Kember, Rachel L; Kentistou, Katherine A; Kim, Daeeun; Kim, Han-Na; Kim, Young Jin; Kleber, Marcus E; Knol, Maria J; Kurbasic, Azra; Lauzon, Marie; Le, Phuong; Lea, Rodney; Lee, Jong-Young; Lee, Wen-Jane; Leonard, Hampton L; Li, Hengtong; Li, Shengchao A; Li, Xiaohui; Li, Xiaoyin; Liang, Jingjing; Lin, Honghuang; Lin, Kuang; Liu, Jun; Liu, Xueping; Lo, Ken Sin; Long, Jirong; Lores-Motta, Laura; Luan, Jian’an; Lyssenko, Valeriya; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Malik, Md Zubbair; Mamakou, Vasiliki; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Mattheisen, Manuel; McDaid, Aaron F; Mei, Quanshun; Meiselbach, Heike; Melendez, Tori L; Milaneschi, Yuri; Miller, Jason E; Millwood, Iona Y; Mishra, Pashupati P; Mitchell, Ruth E; Møllehave, Line T; Mononen, Nina; Mucha, Sören; Munz, Matthias; Mykkänen, Juha; Nakatochi, Masahiro; Nardone, Giuseppe Giovanni; Nelson, Christopher P; Nethander, Maria; Nho, Chu Won; Nielsen, Aneta A; Nolte, Ilja M; Nongmaithem, Suraj S; Noordam, Raymond; Ntalla, Ioanna; Nutile, Teresa; Pandit, Anita; Pauper, Marc; Petersen, Eva R B; Petersen, Liselotte V; Piluso, Francesco; Polašek, Ozren; Poveda, Alaitz; Pyarajan, Saiju; Raffield, Laura M; Rakugi, Hiromi; Ramirez, Julia; Rasheed, Asif; Raven, Dennis; Rayner, Nigel W; Riveros, Carlos; Rohde, Rebecca; Ruggiero, Daniela; Ruotsalainen, Sanni E; Ryan, Kathleen A; Sabater-Lleal, Maria; Santin, Aurora; Saxena, Richa; Scholz, Markus; Shen, Botong; Shi, Jingchunzi; Shin, Jae Hun; Sidore, Carlo; Sidorenko, Julia; Sim, Xueling; Slieker, Roderick C; Smith, Albert V; Smith, Jennifer A; Smyth, Laura J; Southam, Lorraine; Steinthorsdottir, Valgerdur; Sun, Liang; Takeuchi, Fumihiko; Taylor, Kent D; Tayo, Bamidele O; Tcheandjieu, Catherine; Terzikhan, Natalie; Tesolin, Paola; Teumer, Alexander; Theusch, Elizabeth; Thompson, Deborah J; Thorleifsson, Gudmar; Timmers, Paul R H J; Trompet, Stella; Turman, Constance; Vaccargiu, Simona; van der Laan, Sander W; van der Most, Peter J; van Klinken, Jan B; van Setten, Jessica; Verma, Shefali S; Verweij, Niek; Veturi, Yogasudha; Wang, Carol A; Wang, Chaolong; Wang, Jun-Sing; Wang, Lihua; Wang, Ya Xing; Wang, Zhe; Warren, Helen R; Bin Wei, Wen; Wen, Wanqing; Wheeler, William A; Wickremasinghe, Ananda R; Wielscher, Matthias; Winsvold, Bendik S; Wong, Andrew; Wuttke, Matthias; Xia, Rui; Yamamoto, Ken; Yang, Jingyun; Yao, Jie; Young, Hannah; Yousri, Noha A; Yu, Lei; Zeng, Lingyao; Zhang, Weihua; Zhang, Xinyuan; Zhao, Jing-Hua; Zhao, Wei; Zhou, Wei; Zimmermann, Martina E; Zoledziewska, Magdalena; ‘t Hart, Leen M; Adair, Linda S; Adams, Hieab H H; Aguilar-Salinas, Carlos A; Al-Mulla, Fahd; Arnett, Donna K; Asselbergs, Folkert W; Åsvold, Bjørn Olav; Attia, John; Banas, Bernhard; Bandinelli, Stefania; Beilin, Lawrence J; Bennett, David A; Bergler, Tobias; Bharadwaj, Dwaipayan; Biino, Ginevra; Boerwinkle, Eric; Böger, Carsten A; Borja, Judith B; Bouchard, Claude; Bowden, Donald W; Brandslund, Ivan; Brumpton, Ben; Buring, Julie E; Caulfield, Mark J; Chambers, John C; Chandak, Giriraj R; Chanock, Stephen J; Chaturvedi, Nish; Ida Chen, Yii-Der; Chen, Zhengming; Cheng, Ching-Yu; Cho, Yoon Shin; Christensen, Kaare; Christophersen, Ingrid E; Ciullo, Marina; Cole, John W; Collins, Francis S; Concas, Maria Pina; Cooper, Richard S; Cruz, Miguel; Cucca, Francesco; Cutler, Michael J; Damrauer, Scott M; Dantoft, Thomas M; de Borst, Gert J; de Geus, Eco J C; de Groot, Lisette C P G M; De Jager, Philip L; de Kleijn, Dominique P V; de Silva, H Janaka; Dedoussis, George V; den Hollander, Anneke I; Du, Shufa; Easton, Douglas F; Eckardt, Kai-Uwe; Elders, Petra J M; Eliassen, A Heather; Ellinor, Patrick T; Elmståhl, Sölve; Erdmann, Jeanette; Evans, Michele K; Fatkin, Diane; Feenstra, Bjarke; Feitosa, Mary F; Ferrucci, Luigi; Florez, Jose C; Ford, Ian; Fornage, Myriam; Franke, Andre; Franks, Paul W; Freedman, Barry I; Gieger, Christian; Girotto, Giorgia; Golightly, Yvonne M; Gonzalez-Villalpando, Clicerio; Gordon-Larsen, Penny; Grallert, Harald; Grant, Struan F A; Grarup, Niels; Griffiths, Lyn; Gudnason, Vilmundur; Haiman, Christopher; Hakonarson, Hakon; Hansen, Torben; Hartman, Catharina A; Hattersley, Andrew T; Hayward, Caroline; Heid, Iris M; Heng, Chew-Kiat; Hengstenberg, Christian; Herzig, Karl-Heinz; Hewitt, Alex W; Hishigaki, Haretsugu; Hougaard, David M; Hoyng, Carel B; Huang, Paul L; Huang, Wei; Huang, Wen-Yi; Huffman, Jennifer E; Hunt, Steven C; Hutri, Nina; Hveem, Kristian; Hyppönen, Elina; Iacono, William G; Ichihara, Sahoko; Ikram, M Arfan; Isasi, Carmen R; Jarvelin, Marjo-Riitta; Jin, Zi-Bing; Jöckel, Karl-Heinz; Jonas, Jost B; Joshi, Peter K; Jousilahti, Pekka; Jukema, J Wouter; Kähönen, Mika; Kamatani, Yoichiro; Kang, Kui Dong; Kaprio, Jaakko; Kardia, Sharon L R; Karpe, Fredrik; Kato, Norihiro; Kavousi, Maryam; Kee, Frank; Kessler, Thorsten; Khera, Amit V; Khor, Chiea Chuen; Kiemeney, Lambertus A L M; Kim, Bong-Jo; Kim, Eung Kweon; Kim, Hyung-Lae; Kirchhof, Paulus; Kivimaki, Mika; Koh, Woon-Puay; Koistinen, Heikki A; Kokkinos, Alexander; Kooner, Jaspal S; Kooperberg, Charles; Kovacs, Peter; Kraaijeveld, Adriaan; Kraft, Peter; Krauss, Ronald M; Kumari, Meena; Kutalik, Zoltan; Laakso, Markku; Lange, Leslie A; Langenberg, Claudia; Launer, Lenore J; Lee, Hyejin; Lee, Nanette R; Lehtimäki, Terho; Lemaitre, Rozenn N; Li, Huaixing; Li, Liming; Lieb, Wolfgang; Lin, Xu; Lind, Lars; Linneberg, Allan; Liu, Ching-Ti; Liu, Jianjun; Loeffler, Markus; London, Barry; Lu, Fan; Lubitz, Steven A; Mackey, David A; Magnusson, Patrik K E; Manson, JoAnn E; Marcus, Gregory M; Marques Vidal, Pedro; Martin, Nicholas G; März, Winfried; Matsuda, Fumihiko; McCarthy, Mark I; McGarrah, Robert W; McGue, Matt; McKnight, Amy Jayne; Medland, Sarah E; Mellström, Dan; Metspalu, Andres; Mitchell, Braxton D; Mitchell, Paul; Mook-Kanamori, Dennis O; Mori, Trevor A; Morris, Andrew D; Mucci, Lorelei A; Munroe, Patricia B; Nalls, Mike A; Nazarian, Saman; Nelson, Amanda E; Neville, Matt J; Newton-Cheh, Christopher; Nielsen, Christopher S; Niinikoski, Harri; Nikus, Kjell; Nöthen, Markus M; Ogunniyi, Adesola; Ohlsson, Claes; Oldehinkel, Albertine J; Orozco, Lorena; Pahkala, Katja; Pajukanta, Päivi; Palmer, Colin N A; Parra, Esteban J; Pattaro, Cristian; Pedersen, Oluf; Pennell, Craig E; Penninx, Brenda W J H; Perusse, Louis; Peters, Annette; Peyser, Patricia A; Porteous, David J; Posthuma, Danielle; Power, Chris; Pramstaller, Peter P; Province, Michael A; Psaty, Bruce M; Qi, Qibin; Qu, Jia; Rader, Daniel J; Raitakari, Olli T; Rallidis, Loukianos S; Rao, Dabeeru C; Redline, Susan; Reilly, Dermot F; Reiner, Alexander P; Rhee, Sang Youl; Ridker, Paul M; Rienstra, Michiel; Ripatti, Samuli; Ritchie, Marylyn D; Rivadeneira, Fernando; Roden, Dan M; Rosendaal, Frits R; Rotter, Jerome I; Rudan, Igor; Rutters, Femke; Ryu, Seungho; Sabanayagam, Charumathi; Salako, Babatunde; Saleheen, Danish; Salomaa, Veikko; Samani, Nilesh J; Sanghera, Dharambir K; Sattar, Naveed; Schmidt, Börge; Schmidt, Helena; Schmidt, Reinhold; Schulze, Matthias B; Schunkert, Heribert; Scott, Laura J; Scott, Rodney J; Sever, Peter; Sheu, Wayne H H; Shoemaker, M Benjamin; Shu, Xiao-Ou; Simonsick, Eleanor M; Sims, Mario; Singleton, Andrew B; Sinner, Moritz F; Smith, J Gustav; Snieder, Harold; Spector, Tim D; Spedicati, Beatrice; Stampfer, Meir J; Stark, Klaus J; Strachan, David P; Tabara, Yasuharu; Tai, E Shyong; Tang, Hua; Tardif, Jean-Claude; Thanaraj, Thangavel A; Tönjes, Anke; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Tusié-Luna, Maria-Teresa; van Dam, Rob M; van der Harst, Pim; Van der Velde, Nathalie; van Duijn, Cornelia M; van Schoor, Natasja M; Vitart, Veronique; Vohl, Marie-Claude; Völker, Uwe; Vollenweider, Peter; Völzke, Henry; Vrieze, Scott; Wacher-Rodarte, Niels H; Walker, Mark; Wander, Gurpreet S; Wareham, Nicholas J; Watanabe, Richard M; Watkins, Hugh; Weir, David R; Werge, Thomas M; Widen, Elisabeth; Willemsen, Gonneke; Willett, Walter C; Wilson, James F; Wilson, Peter W F; Wong, Tien Y; Woo, Jeong-Taek; Wright, Alan F; Xu, Huichun; Yajnik, Chittaranjan S; Yang, Jian; Yokota, Mitsuhiro; Yuan, Jian-Min; Zeggini, Eleftheria; Zemel, Babette S; Zheng, Wei; Zhu, Xiaofeng; Zillikens, M Carola; Zonderman, Alan B; Zwart, John-Anker; Abecasis, Goncalo R; Assimes, Themistocles L; Auton, Adam; Boehnke, Michael; Chasman, Daniel I; Esko, Tõnu; Stefansson, Kari; Lettre, Guillaume; Lindgren, Cecilia M; Ng, Maggie C Y; O’Donnell, Christopher J; Thorsteinsdottir, Unnur; Visscher, Peter M; Walters, Robin G; Winkler, Thomas W; Wood, Andrew R; Deloukas, Panos; Frayling, Timothy M; Justice, Anne E; Kilpeläinen, Tuomas O; Locke, Adam E; Mohlke, Karen L; North, Kari E; Okada, Yukinori; Willer, Cristen J; Young, Kristin L; Fatumo, Segun; McCaffery, Jeanne M; Timpson, Nicholas J; Hirschhorn, Joel N; Sun, Yan V; Berndt, Sonja I; Loos, Ruth J F; 23andMe Research Team; DiscovEHR (DiscovEHR and MyCode Community Health Initiative); eMERGE (Electronic Medical Records and Genomics Network); GPC-UGR; The PRACTICAL Consortium; Understanding Society Scientific Group; VA Million Veteran Program

Nature medicine

1078-8956

1546-170X

1078-8956

63771

3

Yes

2025

2025

[Published: 21 July 2025]

1-38

10.1038/s41591-025-03827-z

English

Yes

Yes