GLS2 links glutamine metabolism and atherosclerosis by remodeling artery walls

3111 Biomedicine

This work was supported by grants from the European Research Council consolidator program (ERC2016COG724838), Agence Nationale de la Recherche (ANR19-CE17-0030-DS, ANR24-CE14-Glutacare) and the Fondation de France to L.Y.C and the Société Francophone du Diabète to B.B.M. MESA is supported by contracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the National Heart, Lung, and Blood Institute and by grants UL1-TR-000040, UL1-TR-001079 and UL1-TR-001420 from the National Center for Advancing Translational Sciences and by grant R01HL127637 to S.S. This publication was developed under STAR research assistance agreements, no. RD831697 (MESA Air) and RD-83830001 (MESA Air Next Stage), awarded by the US Environmental Protection Agency (EPA).

The data that support the findings of this study are available within the paper and its supplementary information. Other information is available from the corresponding authors upon reasonable request. snRNA-seq data have been deposited at the Gene Expression Omnibus (accession number GSE269682). RNA-seq data of aortas, livers and SMC line (MOVAS) have been deposited at the Gene Expression Omnibus under accession numbers GSE270056 and GSE270058, respectively. Source data are provided with this paper.